There is an urgent need of a simple, inexpensive and reliable serologic test to differentiate general paresis, and especially incipient general paresis, from other forms of neurosyphilis. The colloidal benzoin reaction of the spinal fluid, first advocated by Guillain, Laroche, and Lechelle1 as a specific test for neurosyphilis seems more nearly to fulfil these requirements than either the Lange2 colloidal gold test or the gum mastic test of Emanuel.3
Warwick and Nixon,4 using the colloidal gold test, found that out of a total number of twenty spinal fluids from paretic patients, there were two so-called second or tabetic zone curves, and out of seventy-three spinal fluids from tabetic patients there were seven so-called first or paretic zone curves. The error was about 10 per cent, in each. Warwick5 later, in discussing the effect of treatment on the colloidal gold reaction, gave the curves obtained with
OSBORNE ED. CLINICAL AND SEROLOGIC VALUE OF THE COLLOIDAL BENZOIN REACTION. Arch Derm Syphilol. 1925;12(5):706–719. doi:10.1001/archderm.1925.02370110095011
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