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February 1926

BISMUTH SALICYLATE IN EXPERIMENTAL RABBIT SYPHILISA STUDY OF TOXICITY, ABSORPTION, ELIMINATION AND SPIROCHETICIDAL POWER

Arch Derm Syphilol. 1926;13(2):195-214. doi:10.1001/archderm.1926.02370140061004
Abstract

A great number of research workers in this country and abroad are devoting their time to finding new and better antisyphilitic drugs. Recently, Sazerac and Levaditi1 demonstrated spirocheticidal activity of bismuth in experimental and clinical syphilis. Fournier and Guenot2 followed the initial reports of Sazerac and Levaditi with extensive clinical observations on 200 syphilitic patients. Since these reports the literature abounds with reports of favorable clinical action of bismuth in the treatment of syphilis.

In this country, McCafferty,3 Pardo-Castello4 (Cuba), Hopkins,5 and Klauder6 have presented clinical and experimental findings. In France, Sazerac and Levaditi,1 Levaditi,7 Fournier and Guenot,2 and in Germany, Kolle,8 Bieder,9 and Giemsa10 have given extensive reviews of the literature as well as their own clinical and experimental findings.

The use of bismuth in the treatment of syphilis by Masucci11 dates back to 1899. Syphilitic

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