In 1917, Engman and McGarry1 reported three cases of trichophytosis barbae in which the patients were treated with Strickler's ringworm vaccine. We were struck at that time, although the injections were made subcutaneously, with the systemic reaction and fever produced by the vaccine. Previously Engman and McGarry2 published results on the treatment of various skin diseases by intravenous injection of foreign proteins. In the latter publication, we called attention to the high temperature and extreme general reaction shown in every case by the foreign protein used in those investigations, namely, suspensions of typhoid bacilli. Reasoning from the similar reaction produced by the typhoid suspensions and the ringworm vaccine, we concluded that probably the results obtained in tricophytosis barbae were due to a foreign protein reaction and were not the result of a specific effect of the ringworm vaccine. Therefore, at the first opportunity, cases of large spored ringworm
ENGMAN MF. XLV.—LARGE SPORED RINGWORM INFECTION: TREATMENT WITH FOREIGN PROTEIN INJECTIONS (BEARD AND SCALP). Arch Derm Syphilol. 1926;13(3):352–358. doi:10.1001/archderm.1926.02370150054006
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