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June 1926


Arch Derm Syphilol. 1926;13(6):782-793. doi:10.1001/archderm.1926.02370180047003

The syndrome of Fox-Fordyce disease was first described in 1902 by the men whose name it bears. The cases that have since become known have not added any essentially new characteristics. The symptoms of the disease are constant, and consist of small follicular nodules in the axillae, the mammillary region, the mons veneris and occasionally on the vulva. These nodules are often arranged in parallel rows or columns, presenting only slight inflammatory manifestations of the adjacent skin area, but are accompanied by severe itching, which resists all forms of treatment. We have not made any progress in our knowledge of the pathogenesis of the condition since it was first described. For the most part, investigators have been content to classify it as a "nervous" condition belonging to the neurodermatitis group. During observation of my cases, which, true to type, presented localizations on the axillae, mammae and pubes, the regularity and