The prophylaxis of syphilis, or, more properly speaking,1 the early abortive treatment for syphilis with injection of arsphenamine a short time after exposure, has been used effectively for some time. In accord with the suggestion of Stokes,2 the exposed person should have an injection of arsphenamine intravenously as soon as possible (before forty-eight hours) and another one twenty-four hours later. Michel and Goodman,3 Simon4 and several foreign observers have reported numerous successes in patients treated with repeated injections of the arsphenamines. Greenbaum and Harkins5 have remarked on the paucity of case reports dealing with sterilization accomplished with a single injection of arsphenamine. I have had several such dubious successes, but the doubt has always persisted as to whether or not such persons were really infected.
The following case is of importance because of the failure of one injection of neo-arsphenamine to protect from syphilis.
SUTTON IC. FAILURE OF EARLY ABORTIVE TREATMENT FOR SYPHILISREPORT OF A CASE. Arch Derm Syphilol. 1926;13(6):822–823. doi:10.1001/archderm.1926.02370180087008
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