The presence of lymphatic gland inflammation, especially in the groins, is usually the result of venereal disease, syphilis, chancroid or gonorrhea. Occasionally, it is the result of balanoposthitis, herpes or local pyogenic infections. In other cases lymphatic masses are caused by a systemic process like Hodgkin's disease, leukemia, etc., by malignant growths or by infectious diseases like bubonic plague.
As a rule it is relatively easy to diagnose the cause of a lymphatic enlargement, but for many years certain cases of adenitis have been puzzling to the medical profession. As early as 1859 and 1865, Chassaignac1 and Velpau,2 French surgeons, described cases of lymphatic masses of the groins of peculiar character. Nélaton,3 Hardy4 and other physicians of the second half of the nineteenth century also reported cases of acute or subacutintra-ammation of the lymphatic glands of the groin with the peculiar pathologic characteristic of intraganglionar abscess
PARDO-CASTELLO V. LYMPHOGRANULOMATOSIS INGUINALIS. Arch Derm Syphilol. 1926;14(1):35–45. doi:10.1001/archderm.1926.02370190048006
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