Included as a phase of immunity is a contrary state, namely, anaphylaxis, in which the defense mechanism of the body assumes a destructive character. Immune reactions of the body are commonly brought about by the action of and find expression in the elaboration of substances of a protein nature, antigen and antibody. The same holds true in certain self-destructive reactions of the body, such as anaphylaxis. On this common basis of protein reaction the concept of anaphylaxis has come to be regarded as a phase of immunity.
However, both clinically and experimentally many reactions have been observed of a nature similar to anaphylaxis in which proteins apparently take no part. To include these nonprotein reactions and at the same time to emphasize their essential similarity to protein reactions, von Pirquet1 in 1905 coined a new word, "allergy," which he defined as "an altered reactivity." As is evident, this definition
PINESS G, MILLER H. CUTANEOUS MANIFESTATIONS OF PROTEIN ALLERGY. Arch Derm Syphilol. 1926;14(2):145–157. doi:10.1001/archderm.1926.02370200037004
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