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Article
November 1926

CALCIFICATION OF THE SKIN, INCLUDING THE EPIDERM, IN CONNECTION WITH EXTENSIVE BONE RESORPTION

Arch Derm Syphilol. 1926;14(5):503-532. doi:10.1001/archderm.1926.02370230002001
Abstract

The occurrence of calcium deposits in the skin, while not frequent, is such a spectacular phenomenon that it has received a full measure of attention in the literature, and its mention does not arouse special curiosity. In the face of all this, and in extenuation of this paper, we submit that our case was, as far as we could find, unique in that the epiderm and other epithelial structures were heavily calcified and that it was unusual in the following respects: 1. Many of the appendages, particularly neural ones, were affected. 2. It occurred apart from any recognizable retrogressive changes, preceding or otherwise, and therefore may probably be classed among the extremely rare examples of metastic calcification—the "kalkmetastase" of the Germans. If this is true, the skin would constitute another and new approach to the diagnosis of morbid internal states, for the histologic examination of the skin gave the first

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