REVIEW OF PRIOR STUDIES
In a previous communication1 we reported results of a study of the irritability of the skin of rabbits and cats to chemical irritants under experimentally induced conditions. Prior to experimentation (the animals on a mixed diet), a definite amount of different dilutions of croton oil in olive oil and a 10 per cent solution of turpentine in olive oil was applied to the skin of one side of the animal. The reaction thus caused (expressed in terms of ± to +++) was compared to the reaction resulting from a similar application on the untreated side of the same animal after experimentations. There was a considerable variation in the cutaneous reaction of different animals, under normal conditions, to the aforementioned applications. No variation in the cutaneous reaction to these applications was noted in the same animal, under normal conditions, examined at varying intervals.In these studies it
KLAUDER JV, BROWN H. EXPERIMENTAL STUDIES IN ECZEMA: II. A CORRELATION OF THE CHEMISTRY WITH THE IRRITABILITY OF THE SKIN OF ANIMALS UNDER NORMAL AND UNDER EXPERIMENTALLY INDUCED CONDITIONS. Arch Derm Syphilol. 1927;15(1):1–15. doi:10.1001/archderm.1927.02370250014001
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