The first use of gold in lupus erythematosus was doubtless based on the assumption that this disease was of tuberculous origin, for gold was employed in tuberculosis according to White1 as far back as 1810 by Chrestien. Robert Koch, however, in 1890, gave the impetus to the use of gold after he had demonstrated its effect on the tubercle bacillus in vitro.
Bruck and Glück2 were the first in recent years to institute treatment with gold in tuberculosis. These investigators tried the effect of potassium gold cyanide injections intravenously in lupus vulgaris. They state that "there is no doubt that by intravenous injection of potassium-gold cyanide, without local treatment, a striking improvement in lupus lesions is produced." This is justified by the photographs published by them which leave no doubt as to the demonstrably favorable effects on the cutaneous lesions. No complete cures were effected however. The influence
SCHAMBERG JF, WRIGHT CS. THE USE OF GOLD AND SODIUM THIOSULPHATE IN THE TREATMENT OF LUPUS ERYTHEMATOSUS. Arch Derm Syphilol. 1927;15(2):119–137. doi:10.1001/archderm.1927.02370260003001
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