During the last few years, from time to time, cases have appeared in medical literature, presenting a blood picture suggestive of an aplastic pernicious anemia with cutaneous hemorrhages and no apparent visceral changes following treatment with neoarsphenamine and sulpharsphenamine, particularly, the former. Every one who has treated many patients with syphilis has occasionally been unfortunate enough to have had a toxic effect of medication with cutaneous manifestations. I am reporting the first hemorrhagic case which I have observed, after approximately four thousand injections of the arsphenamines. Its exceptional severity and unusual character, coupled with several points of particular interest, seem sufficient to warrant a brief report and discussion.
REPORT OF CASE
History.—
A B., a man, aged 54, married, was sent to me in the summer of 1925 with definite physical signs of beginning tabes dorsalis. The Wassermann reaction was four plus to both alcoholic and cholesterinized antigens in the