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July 1927

LATTICE FIBERSTHEIR DIAGNOSTIC VALUE IN EPITHELIOMA

Author Affiliations

Clinical Instructor in Dermatology, Stanford University SAN FRANCISCO

Arch Derm Syphilol. 1927;16(1):25-34. doi:10.1001/archderm.1927.02380010038005
Abstract

In normal connective tissues, such as the corium, there are fibrils, fibers and bundles of mesenchymal origin that stain with ordinary connective tissue stains (Van Gieson's). Specific stains for elastic tissue demonstrate another type of fiber and fibril, the elastic fibers of the area. In pathologic conditions, such as inflammatory and neoplastic processes, delicate fibrils appear which are specifically stained only by silver impregnation methods. These delicate, immature connective tissue fibrils are termed lattice fibers or "Gitterfasern." They often form a close-meshed network, yet they should be carefully differentiated from the older connective tissue fibers and from the elastic tissue fibers that occur in normal conditions.

When produced experimentally, as in the trichophytin reaction, lattice fibers may be observed as early as the end of the second day, according to Way and Klövekorn.1 They are first seen around the small arterioles, from the endothelial cells of which they appear

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