The first experimental study of the effect of elevations of body temperature on the disease phenomena of syphilis was undertaken by Weichbrodt and Jahnel.1 The exposure of rabbits with scrotal chancres to an incubator temperature of 105.8 F. (41 C.) for thirty minutes twice daily, over several consecutive days, resulted in a lessened motility and a progressive decrease of spirochetes in serum obtained from the lesions. Simultaneously, the chancres underwent gradual involution to complete healing in from three to five weeks. Rectal temperatures of from 107.6 to 111.2 F. (42 to 44 C.), and occasionally 113.0 F. (45 C.), were produced in the animals.
Recently, Schamberg and Rule2 have been able to prevent the development of an infection following the intratesticular inoculation of rabbits with syphilitic virus. Beginning three and four days after inoculation, the animals received from ten to eleven baths each, lasting from fifteen to twenty
FRAZIER CN. EFFECT OF ELEVATION OF BODY TEMPERATURE ON THE COURSE OF EXPERIMENTAL SYPHILIS IN THE RABBIT. Arch Derm Syphilol. 1927;16(4):445–455. doi:10.1001/archderm.1927.02380040066004
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