We possess a convincing array of evidence that the squamous and vesicular dermatoses of the palms and soles, as well as of the webbed spaces between the toes and fingers, are due to a mycotic infection when they are not caused by an obvious external irritation. We have not been altogether fortunate in arriving at a thoroughly satisfactory therapeutic procedure for these cases. Iodine, sulphur, chrysarobin, salicylic acid, benzoic acid and many other drugs,1 and, finally, the roentgen ray, severally and in combination, have been recommended as ameliorative of this condition.
When a procedure for eradicating the infection is selected, the depth in the epidermis at which the fungi are harbored must be considered. Manifestly, the deep epidermal vesicles in the somewhat calloused soles demand a more strenuous keratolytic agent to uncap and evacuate them than would the squamous type of lesion on the palms. And so, a specific
SHARLIT H, HIGHMAN WJ. THE USE OF TETRAIODOMETHENAMINE IN FLEXIBLE COLLODION IN THE TREATMENT OF DERMATOPHYTOSIS. Arch Derm Syphilol. 1927;16(6):697–705. doi:10.1001/archderm.1927.02380060016002
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