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In the issue of June 18, 1927, of the Journal of the American Medical Association, Dr. C. White and Dr. F. D. Weidman published an article entitled "Pseudo-Epitheliomatous Hyperplasia at the Margins of Cutaneous Ulcers with Special Reference to Histologic Diagnosis." It brings up a matter of great importance, namely, the unreliability of histologic diagnosis of epithelioma in ulcers of the skin. The gist of the article is as follows: Epithelial hyperplasia at the margin of nonmalignant cutaneous ulcers may mimic malignant changes so closely that the histologic diagnosis of epithelioma may be made where epithelioma actually does not exist. The authors' studies on this subject show that the final decision must be made on the basis of the clinical behavior of the lesion. They describe types of nonmalignant hyperplasia, from that of pronounced acanthosis to those showing all the characteristics of squamous cell cancer. The two histologic features
THE HISTOLOGIC DIAGNOSIS OF CUTANEOUS CANCER. Arch Derm Syphilol. 1927;16(6):755–756. doi:10.1001/archderm.1927.02380060074007
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