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Article
January 1928

DERMO-EPIDERMIC INTERCHANGES: AS CONTROLLED BY THE STUDY OF MELANIC PIGMENT, THE ESTERS OF CHOLESTEROL (XANTHOMA) AND HEMOSIDERIN (SCHAMBERG'S DISEASE)

Author Affiliations

STRASBOURG, FRANCE

Arch Derm Syphilol. 1928;17(1):1-15. doi:10.1001/archderm.1928.02380070014001
Abstract

The nature of the relation connection between the epidermis and the corium is a problem that has confronted every dermatologist who has studied the normal histology of the skin.

Two main facts seem to have been noted and to have helped dermatologists to build up the classic conception. The first fact is the idea that the epidermis and the derma are of different origin, one being formed from the ectoderm, the other from the mesoderm. The dogma of the specificity of the two layers and their products, which has been unshaken for a long time, has brought observers to believe in a complete morphologic separation of the two tissues that their topography and function bring together to form a single organism, complex perhaps, but indivisible.

The second fact is the absence of blood vessels in the epidermis. As soon as it was proved that no blood vessels were in the

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