Our interest in this problem was aroused by the failure of general treatment in a pronounced case of argyria in a teacher who had been given mild silver protein by mouth for the treatment of gastric ulcer. After an exploratory laparotomy the medication was begun, 5 grains (0.33 Gm.) being given three times daily for about three months. The patient then noticed a change in the color of her skin, but because she obtained relief from the severe gastric pains, she continued the use of the drug for a year longer, taking only 5 grains once a day. Thirteen years after this she consulted one of us (A. W. S.). At that time her face was a dark slate color, the hands were light gray, and the discoloration of the rest of the skin was slight. Some discoloration of the sclerae and the buccal mucous membrane was also present. A
STILLIANS AW, LAWLESS TK. AN INTRACUTANEOUS METHOD OF TREATING ARGYRIAA PRELIMINARY REPORT. Arch Derm Syphilol. 1928;17(2):153–155. doi:10.1001/archderm.1928.02380080003001
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