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February 1928


Arch Derm Syphilol. 1928;17(2):156-181. doi:10.1001/archderm.1928.02380080006002

Lymphogranulomatosis is a systemic disease that may present a great variety of early clinical signs and symptoms. This is particularly true in regard to the skin manifestations associated with it. A thorough study and a correct interpretation of these cutaneous symptoms may give the first clue as to the existence of the disease. In some patients, an eruption on the skin may precede the generalized adenopathy by a period of many months or years. There are other patients whose cases the internist, the dermatologist and the pathologist are unable to classify definitely before necropsy. In this paper, I shall present the report of a few of these cases, with dermatologic aspects of particular interest.

In 1832, Hodgkin1 described seven patients who had, in common, an enlargement of the lymph nodes of the body. In the years that followed, Virchow,2 Cohnheim,3 Kundrat,4 Sternberg5 and Reed,6