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April 1928

Die Malariatherapie der Syphilis

Arch Derm Syphilol. 1928;17(4):576. doi:10.1001/archderm.1928.02380100130014

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This monograph of about eighty pages presents the results of work which was begun by the late Kyrle in 1922 and carried on to conclusion by the authors, who were associated with him in the work. Kyrle and his co-workers have applied the inoculation of malaria not only in cases of neurosyphilis, but in a large number of cases of other forms of syphilitic infection, including early syphilis of all types, syphilis complicated by gravidity, congenital syphilis and visceral syphilis. Combined with this was a course of treatment with neoarsphenamine.

In addition to the treatment of patients with active syphilis, the authors subjected a large number of patients with latent and asymptomatic syphilis with positive Wassermann reactions to the malarial regimen in an endeavor to determine the effect of such treatment on the Wassermann reaction. In general, the malaria was allowed to persist until eight or ten chills had occurred.

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