Pellagra, like most diseases which occur endemically, begins to show changes in its clinical manifestation as adaptation to environment occurs or as the disease becomes milder. In order to determine these clinical manifestations, a study was made of 125 cases of pellagra, occurring in the John Sealy Hospital in Galveston, special attention being paid to the conditions of the skin and mucous membrane.
Pellagra originated in the United States in 1902,1 but first received attention in a report from Alabama in 1906.2
Much has been written on the etiology, symptomatology and pathology of the condition. Speculation and theory have ranged from the probability of infection from spoiled maize to the factors of intoxication and diet and the later vitamin theories.3 At present some unknown factors in the etiology of pellagra still remain.
Some months ago, I became enthusiastic on finding a spirochete in the blood in three
CRUTCHFIELD ED. PELLAGRAWITH SPECIAL REFERENCE TO THE SKIN AND MUCOUS MEMBRANE. Arch Derm Syphilol. 1928;17(5):650–658. doi:10.1001/archderm.1928.02380110068006
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