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May 1928


Arch Derm Syphilol. 1928;17(5):721-727. doi:10.1001/archderm.1928.02380110139014

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Treatment in Cases of Erythema Induratum with Gold Thiosulphate. Presented by Dr. Clark.  Mrs. J. W., a housewife, aged 43, born in the United States, began to have "lumps" on the calves of both legs thirteen years prior to presentation. These apparently appeared at intervals for about three years, and then the lesions began to show a tendency to break down. Since then the patient had had new tumors appearing constantly on the lower part of the legs, practically all of which would ulcerate, leaving scars. Many kinds of treatment that had been tried had failed.When the patient was first seen eight months before presentation, examination showed an unusual amount of ulceration and scarring from active and old, healed lesions, mostly on the calves of both legs. The ulcerations were almost as numerous and extensive as one ever sees in this condition. The Wassermann test was negative, and symptoms of syphilis were not present.Eight months prior to presentation the patient was given biweekly injections of 100 Mg. of a gold compound. After seven weeks of these injections, the patient developed a slight dryness and itching of the skin, and this treatment was stopped for three weeks ; sodium thiosulphate was then given intravenously,

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