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To the Editor:—
During the fiftieth meeting of the American Dermatological Association (April 30, 1927) Dr. Ketron (Arch. Dermat. & Syph.16:642 [Nov.] 1927) presented a patient suffering from keratosis and cancer on the palms and soles. Most of the physicians present were of the opinion that the cancer in question was due to arsenic, but Dr. Ketron considered that the quantity of arsenic (74 mg. per kilogram) contained in the brass filings was too small to cause cancer arsenicalis.However, Professor Bayet (Cong. du Cancer 1:15, 1923), referring to the works of the English specialists, declared that 30 mg. of arsenic per kilogram of pitch was sufficient to cause cancer arsenicalis. Professor Bayet affirmed that during experiments, even smaller (as he expressed it, "ionic") quantities of arsenic may produce the same results.Considering, on one hand, Professor Bayet's experiments, and, on the other hand, the clinical picture
Kistiakovsky E. AMOUNT OF ARSENIC NECESSARY TO PRODUCE ARSENICAL CANCER. Arch Derm Syphilol. 1928;17(6):848. doi:10.1001/archderm.1928.02380120083010
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