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July 1928


Arch Derm Syphilol. 1928;18(1):50-73. doi:10.1001/archderm.1928.02380130053004

The term "basal squamous cell epithelioma" is used to designate the transitional forms that occur between basal cell and squamous cell epithelioma. I shall undertake to show that these transitional forms occur frequently, and that their prognosis is serious as compared with basal cell epithelioma. To do this, I shall first review briefly the various aspects of basal cell and squamous cell epithelioma.

BASAL CELL VERSUS SQUAMOUS CELL EPITHELIOMA  Jacob, in 1827, first described what is clinically known as a rodent ulcer. Following Krompecher's work in 1900 and 1903,1 these tumors became known as Basalzellenkrebse. Recently, Krompecher2 coined the term Basaliome to include all basal cell growths, whether benign or malignant. By basal cell epithelioma, however, I refer only to his Basalzellenkrebse.Various theories have been advanced at different times to explain the origin of basal cell epitheliomas, such as that they arise from the epidermis, hair follicles,