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Article
July 1928

ASYMPTOMATIC NEUROSYPHILISV. A COMPARISON OF EARLY AND LATE ASYMPTOMATIC NEUROSYPHILIS

Arch Derm Syphilol. 1928;18(1):99-108. doi:10.1001/archderm.1928.02380130102009
Abstract

In 1922,1 we reported the results of routine examination of the spinal fluid in 352 patients with primary and secondary syphilis who did not present definite clinical evidence of involvement of the central nervous system. It was pointed out that on the basis of the changes in the spinal fluid, early asymptomatic neurosyphilis might be divided into three subgroups. In the first of these (group 1), the fluid changes were minimal, consisting only of pleocytosis and slight increase in globulin, with negative Wassermann and colloidal tests. Another group of patients (group 3) showed spinal fluids with the first zone (general paralytic) formula even in the first few months of the infection, i.e., high cell count, from 50 to 200 or more, the test for globulin strongly positive, Wassermann fixation with small amounts of fluid, 0.1 cc. or less, and colloidal tests of the paralytic type. The intermediate group (group

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