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October 1928


Author Affiliations

Assistant Dermatologist, Massachusetts General Hospital; Dermatologist, Beth Israel Hospital; Assistant in Dermatology, Harvard Medical School; BOSTON

Arch Derm Syphilol. 1928;18(4):534-538. doi:10.1001/archderm.1928.02380160035004

This case is reported because of the rarity of the condition, and because it corroborates the mechaniconervous theory of Darier,1 i. e., intra-abdominal pressure from primary or metastatic malignant neoplasm implicating the nerve structures of the sympathetic system and causing an interference with their normal functions may be said to play an important part in the causation of the integumentary changes peculiar to the disease in adults. Pollitzer2 concurred with this view. In this case, the left suprarenal was likewise involved.

I will not attempt to discuss this rare, yet important and interesting disease. Dr. Fred Wise's paper3 on acanthosis nigricans contains a complete and interesting review of the literature on the subject. However, a tabular comparison of the two forms of acanthosis nigricans, as per Bogrow's monograph,4 is in place:

History.—  G. H., a man, aged 41, single, was admitted to the hospital on Oct. 6, 1925, complaining of abdominal pain.

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