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December 1928


Arch Derm Syphilol. 1928;18(6):862-867. doi:10.1001/archderm.1928.02380180055005

I desire to place on record what appears, as far as I have been able to ascertain, to be a hitherto undescribed staining of the skin with gold following the therapeutic administration of this metal.

A woman, aged 45, suffering from lupus erythematosus of twelve years' standing, received ten injections of a gold compound, with some improvement; after the last treatment, she developed an erythematosquamous dermatitis. She later consulted me, and, owing to her apparent hypersusceptibility, I advised her physician to use a special form of colloidal gold which Mr. H. Brown had prepared in our Research Institute. This preparation is tolerated in white rats in the huge dosage of from 200 to 300 mg. per kilogram, whereas sodium aurothiosulphate is barely tolerated in 35 mg. per kilogram.

One injection was successfully administered by her physician. When the second dose was given, the needle slipped outside the vein, and in

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