REVIEW OF PRIOR STUDIES
In previous communications1 studies were made of the calcium, magnesium, sodium and potassium content of the skin of rabbits under normal conditions, after various diets and after experimentally induced states. The cutaneous irritability of the same animals was first determined by noting the degree of reaction to external applications of dilutions of croton oil.Correlating the degree of irritability and the mineral content of the skin, there appeared to be an inverse relation between the degree of irritability and the amount of calcium, and a direct relation between the degree of irritability and the amount of potassium. The less the irritability of the skin, the greater the likelihood of a high calcium content and a low potassium content; conversely, the more pronounced the irritability, the greater the likelihood of a low calcium content and a high potassium content. This relation was present in the majority,
KLAUDER JV, BROWN H. EXPERIMENTAL STUDIES IN ECZEMA: III. THE ROLE OF THE SYMPATHETIC NERVOUS SYSTEM AND CALCIUM-POTASSIUM RATIO IN ALTERING CUTANEOUS IRRITABILITY IN THE RABBIT. Arch Derm Syphilol. 1929;19(1):52–65. doi:10.1001/archderm.1929.02380190055004
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