The fate of dermatophytes which have made their way into the organism interested observers long before it was known that they cause diseases of a general character. Beginning with the last decade of the past century, numerous authors (Quinke,1 Elsenberg,2 Truffi,3 Citron4 and others) attempted to elucidate the following points: 1. Are cutaneous fungi liable to vegetate in the visceral organs? 2. What toxic effects do they produce in such instances? The question also arose as to the rôle of the skin in cases in which fungi are introduced by way of the blood stream. For that purpose rabbits were inoculated intravenously, intraperitoneally or subcutaneously with cultures of Trichophyton or Achorion respectively, without, however, any resulting positive cutaneous or visceral lesions. In more recent publications, Bloch5 emphatically stated that the subcutaneous or intravenous ways of infection with fungi do not immunize or reproduce the disease
FRIED SM, SEGAL MB. THE HEMATOGENOUS PRODUCTION OF DERMATOMYCOSES: EXPERIMENTAL STUDIES. Arch Derm Syphilol. 1929;19(1):98–104. doi:10.1001/archderm.1929.02380190101008
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