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March 1929


Author Affiliations


From the Department of Dermatology, Jefferson Medical College and Lankenau Hospital.

Arch Derm Syphilol. 1929;19(3):391-408. doi:10.1001/archderm.1929.02380210046004

Acanthosis nigricans is a disease that is full of absorbing interest. It resembles a number of skin diseases; yet it retains its individuality, which enables the observer to ferret out its peculiarities amid a maze of symptoms due to other causes. It has been the subject of many papers, and a great deal has been written about its various aspects. It is our intention to deal at this time with one of the essential questions connected with the etiology of this condition, namely, the relationship of neoplastic tumors of the abdomen and pelvis to the malignant type of acanthosis nigricans and the relationship of congenital malformations, adhesions and benign tumors in the abdominal cavity in the class of patients with acanthosis nigricans described as the juvenile type.

The circumstances under which the mechaniconervous theory of Darier has arisen are of interest. In 1892, Darier1 reported two cases of acanthosis

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