With the introduction of the arsenicals the treatment of syphilis entered on its modern era. While an agreement has not been reached among syphiliographers as to the best single plan of treatment, it is generally accepted that the treatment of patients with this infection should be intensive and that the combination of arsphenamine and mercury or bismuth in one form or another should be used. This in a general way constitutes the modern method of antisyphilitic therapy. This method has now been employed for about fifteen years, and while this is but a brief period in the life cycle of syphilis, it is nevertheless sufficiently long to permit of some evaluation of the results obtained.
In the present study we attempt to analyze and to summarize the results obtained in the treatment of patients with early syphilis. This study is based on 444 cases, in which the patients were treated and observed during the period from 1911 to 1926, in the venereal disease service of the department of health of the city of New York and in the department of dermatology of the Mount Sinai Hospital of New York. These cases were selected from the records of several thousand patients with early syphilis who came under observation in these institutions.
CHARGIN L, STONE A. EARLY SYPHILIS: RESULTS OF TREATMENT IN FOUR HUNDRED AND FORTY-FOUR CASES. Arch Derm Syphilol. 1929;19(5):750–763. doi:10.1001/archderm.1929.02380230040004
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