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Article
June 1929

THE THERAPEUTIC ACTION OF COLLOIDAL MERCURY SULPHIDE (HILLE) AND OF OTHER COLLOIDAL HEAVY METAL SULPHIDES IN SYPHILIS EXPERIMENTALLY PRODUCED IN RABBITS

Author Affiliations

CHICAGO

From the Department of Physiology of the University of Chicago.

Arch Derm Syphilol. 1929;19(6):878-890. doi:10.1001/archderm.1929.02380240013002
Abstract

There are few reports in the literature of investigations on the therapeutic properties of colloidal solutions of the heavy metals or their salts in syphilis experimentally produced. Neisser1 studied the therapeutic activities of colloidal mercury and other colloidal heavy metals in syphilis experimentally produced in monkeys. Evers and Albrecht2 employed a preparation of bismuth and arsenic adsorbed on an organic colloidal complex and also a colloidal solution of bismuth, arsenious acid and gum arabic in the treatment of rabbits in which syphilis had been experimentally produced, and obtained favorable results. Iwasa3 reported encouraging observations with glutin-copper in rabbits experimentally infected with syphilis.

In this communication, the results obtained from the study of the therapeutic activity of colloidal mercury sulphide (HgS), colloidal bismuth sulphide (Bi2S3), colloidal bismuth sulpharsenite (BiAsS3), colloidal copper sulphide (CuS), colloidal copper sulpharsenite (Cu3As2S6) and mervenol (colloidal mercury sulphide and colloidal copper sulphide in equimolecular proportions) in syphilis experimentally brought about in the rabbit are presented.4

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