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Article
June 1929

LOCAL MICROSCOPIC CHANGES FOLLOWING THE ADMINISTRATION OF ANTISYPHILITIC DRUGS

Author Affiliations

DETROIT

From the Medical Research Laboratories, Parke Davis and Company, Detroit, Michigan.

Arch Derm Syphilol. 1929;19(6):922-944. doi:10.1001/archderm.1929.02380240057007
Abstract

The histologic changes induced by the antisyphilitic drugs at the site of injection have attracted comparatively little study, though the clinical incidence of injury is frequent and at times severe.1

In this study I shall attempt to record the pathologic changes induced by the three main types of antisyphilitic drugs-arsenic, mercury and bismuth—in water solutions or in oil suspensions. The experimental work was carried out on rabbits, guinea-pigs and dogs. Arsphenamine was included in this study because of a tendency to revert to its use intramuscularly,2 though the earlier studies of Swift3 and Kolmer4 have called attention to its injurious action on the tissues.

EFFECT OF VARIOUS DRUGS ON THE TISSUES 

Arsphenamine.—  The intramuscular administration of arsphenamine is followed by an immediate severe destruction of the tissues at the site of injection (fig. 1). The necrosis of the tissues of the central portion of the area

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