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Article
June 1929

GROSS AND MICROSCOPIC CHANGES IN THE SKIN PRODUCED BY X-RAYS AND BY LIPOID SOLVENTS

Author Affiliations

ST. LOUIS

From the Departments of Research and Dermatology, The Barnard Free Skin and Cancer Hospital, and published as one of the series of studies, reports and observations from the dermatological departments of the Barnard Free Skin and Cancer Hospital and the School of Medicine, Washington University, St. Louis, Mo., U. S. A., service of Drs. M. F. Engman and W. H. Mook.

Arch Derm Syphilol. 1929;19(6):954-967. doi:10.1001/archderm.1929.02380240089009
Abstract

In a former communication1 we stated that similar histologic changes in the tissue were noted after roentgen burns2 and that lesions were produced in the skin of rats by repeated paintings of tar preparations over a long period of time.

By varying the time period of exposure and by transmitting the ray through an opening 1 cm. in diameter, the remainder of the rat being protected, we have produced various degrees of roentgen burns of the skin. Our observations were begun in February, 1927, and were continued to the time of preparation of this paper. We terminated the experiment because a large percentage of the animals in the series painted with coal tar preparation had died and, as we are especially interested in comparative data, the rest of the animals were killed and autopsies were made.

A large series was started so that one animal from each series

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