A percentage of cases of leukoderma are secondary to fungous infections, to specific diseases such as syphilis and leprosy and to many scaly eruptions such as psoriasis and ringworm. It can also be produced in certain persons by contact with various irritants such as plants, chemicals or even the rays of the sun. Sun rays, therefore, may be accountable for the prevalence of the disease among the inhabitants of tropical regions. Altered photosensitivity plays a more important part in the production of leukoderma than would be ordinarily suspected. With relatively few exceptions, the exposed parts of the body represent the preponderance of areas involved in early cases of leukoderma. It is not unusual, however, to see spots of the disease on other parts of the body.
Gupta1 was of the opinion that the phenomenon is due to allergy. The disease has been known to occur from conditions that produce
LINDSAY HCL. TREATMENT OF LEUKODERMA WITH GOLD SODIUM THIOSULPHATE. Arch Derm Syphilol. 1929;20(1):22–26. doi:10.1001/archderm.1929.01440010030003
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