In 1916, Schamberg1 informally reported favorable results following treatment for dermatitis venenata due to ivy (Rhus toxicodendron) by means of oral administration of an alcoholic extract of the leaves of the plant. He made a formal report2 in 1919, in which he advised two types of treatment: preseasonal prophylactic and seasonal curative. In both treatments, he began with the administration of very small doses (1 or 2 drops) of the alcoholic extract by mouth. In the preseasonal cases the extract was given three times daily, each dose being increased by 1 drop until 21 drops were reached, at which time the dosage was increased to 1 teaspoonful. This dosage was to be continued throughout the season. If dermatitis had already developed, the system of treatment was the same, except that each dose was increased by 2 drops. After the dosage reached 18 drops, it was increased to 1
TEMPLETON HJ. UNTOWARD REACTIONS FOLLOWING TOXIN TREATMENT FOR DERMATITIS VENENATA. Arch Derm Syphilol. 1929;20(1):83–89. doi:10.1001/archderm.1929.01440010091011
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