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August 1929


Author Affiliations


From the Department of Dermatology and Syphilology, New York Post-Graduate School and Hospital and the Laboratory of Biological Chemistry at the College of Physicians and Surgeons, Columbia University.

Arch Derm Syphilol. 1929;20(2):171-175. doi:10.1001/archderm.1929.01440020023004

That cholesterol and lecithin are interrelated in the body economy is a general belief. Especially is this the feeling regarding syphilis. Experiments have not yet proved what the relationships are. They may be purely structural in origin, purely functional or more probably both structural and functional. Indeed, the field seems an extremely fruitful one.

The variations obtained in cholesterol1 made us particularly anxious to ascertain the changes in lecithin. Therefore, while accumulating data on cholesterol, we were investigating the various procedures for the estimation of phosphorus2 or, more specifically, lipin phosphorus.3 It was soon found that the methods involving "test tube" oxidations by sulphuric acid and nitric acid had to be discarded. The danger of bumping with the small amount of reagents used became a source of great concern for microdeterminations.4 This led us to the use of the sulphuric acid and hydrogen dioxide suggestions of

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