The term lymphogranulomatosis is used to designate a clinical syndrome, characterized by a more or less systemic lymphadenosis of a specific histologic character. This disease process has been known more generally under the term "Hodgkin's disease," which, since the classic work of Dorothy Reed, is practically an entity in the American literature. Because the condition that Hodgkin originally described is common to various lymphadenoses, there has been a growing tendency to classify the specific lymphadenosis described by Reed1 under the more comprehensive and descriptive term, lymphogranulomatosis.
Lymphogranulomatosis is primarily a chronic disease of the reticuloendothelial system, involving the lymph nodes, skin, lymphatics and spleen. The clinical symptoms are exceedingly varied, especially the skin manifestations. There is generally a firm and discrete enlargement of some part of the lymphatic system, usually the cervical or inguinal nodes. While the skin manifestations frequently precede the lymphatic enlargement, the diagnosis is seldom made
JONES JW, ALDEN HS. GENERALIZED LYMPHOGRANULOMATOSIS OF THE SKINREPORT OF A CASE IN A NEGRO. Arch Derm Syphilol. 1929;20(2):212–216. doi:10.1001/archderm.1929.01440020064011
Customize your JAMA Network experience by selecting one or more topics from the list below.