Our previous reports on experimental wheals produced through internal channels1 disclosed the fact that such wheals could be produced on most persons with normal skins, by the intradermal injection of serums of certain patients hypersensitive to food, and then feeding these tested subjects the specific offending food. Three types of serums have been employed in these investigations, one sensitive to fish, the second to egg and the third to pistachio nuts. The method of obtaining the serum from the hypersensitive patient was fully discussed in these papers, and all details relative to the production of the wheal were presented.
All experimental observations indicated that the offending substance in the ingested food gained access into the circulation by way of the gastro-intestinal tract in an unaltered state, and was carried in such form to the passively sensitized site.2 As a result of the interaction between the antigen (the circulating
WALZER A. URTICARIA: IV. WHEAL FORMATION ON ABNORMAL SKINS. Arch Derm Syphilol. 1929;20(3):277–302. doi:10.1001/archderm.1929.01440030003001
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