Following the production of tuberculides by Lewandowsky1 by means of intracardial inoculation of tubercle bacilli, Saeves2 produced mycotic infections on the skin of guinea-pigs by hematogenous inoculation of trichophytons (Achorion quinckcanum and Trichophyton gypseum). Kogoj3 and Smolka4 have shown that these mycotic lesions, following hematogenous infection, localize on irritated skin areas. Even earlier Calmette and Guérin,5 as well as Prowazek and Yamamoto,6 had made the observation, which had previously escaped attention, that after hematogenous inoculation of variola virus, lesions appeared on the epilated irritated skin. W. Jadassohn7 observed that trichophytons enter the blood of guinea-pigs quickly after cutaneous inoculation, and thereby explained the immunity which Martenstein8 had observed to follow the early excision of the site of cutaneous inoculation. The fact that bacteria causing skin lesions may enter the regional lymph nodes in a short time has been demonstrated by such work
KESTEN B, MARTENSTEIN H. EXPERIMENTAL SPOROTRICHOSIS: CUTANEOUS AND INTRACARDIAL INOCULATION: A PRELIMINARY REPORT. Arch Derm Syphilol. 1929;20(4):441–444. doi:10.1001/archderm.1929.01440040013002
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