In a recent paper W. Frei1 reported that he had been able to sensitize the skin of guinea-pigs by means of a single intradermal injection of a small quantity of neoarsphenamine. This sensitization could be demonstrated later by the changed reaction of the skin to a second injection of the same substance.
Although some other successful sensitizations of animals to chemically defined substances have been reported in the literature, the experiments of Frei offer a skin hypersensitivity in animals which fulfils an unusually large number of the requirements for experimental research. To my mind, they give a method of investigating processes of hypersensitivity which embodies the following advantages: 1. The substance employed is one which plays an important rôle in conditions of hypersensitivity in human beings (arsphenamine dermatitides) which have already been studied both clinically and experimentally (Klauder,2 Kagelmann,3 Biberstein,4 Frei and Mayer,5 Frei,6
SULZBERGER MB. HYPERSENSITIVENESS TO ARSPHENAMINE IN GUINEA-PIGS: I. EXPERIMENTS IN PREVENTION AND IN DESENSITIZATION. Arch Derm Syphilol. 1929;20(5):669–697. doi:10.1001/archderm.1929.01440050079007
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