In an article on the relation of the acne bacillus to acne vulgaris,1 experimental observations were recorded in which we attempted to infect animals by intravenous and intraperitoneal injections of the acne bacillus. Nine mice and six guinea-pigs were given injections intraperitoneally, seven rabbits intraperitoneally and seven intravenously. None of these animals showed any definite evidence of infection by this organism. In some of the rabbits and guinea-pigs, nodular collections of pus were found under the peritoneum when the bacilli had been introduced intraperitoneally, but we believe that this was only a foreign body reaction since the same phenomenon occurred when dead organisms were injected.
Since this report, two supplementary experiments have been carried out. In one, acne bacilli, strains 46 and 40, were injected intraperitoneally into twenty-four mice. Each of two mice received 0.1, 0.25 and 0.5 cc. of a whole broth culture and a salt solution suspension
KETRON LW, BROWN JH. THE ACNE BACILLUS: EXPERIMENTAL OBSERVATION ON ITS PATHOGENICITY FOR ANIMALS AND MAN. Arch Derm Syphilol. 1929;20(6):835–853. doi:10.1001/archderm.1929.01440060071007
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