Carotinemia is a condition to which von Noorden, in 1904, gave the name "xanthosis diabetica," although it occurs also in nondiabetic patients. He noted that in some diabetic persons a peculiar yellow discoloration of the skin appeared which affected chiefly the palms, soles and face. These patients were maintained on a diet rich in vegetables. Their blood serum became intensely yellow. Van den Bergh and Snapper, in 1913, demonstrated the fact that bilirubinemia did not play a rôle in this discoloration, but that it was due to an excess of lipochromes in the blood stream. That the degree of xanthosis was dependent on the lipochrome content of the blood was later shown by Burger and Rheinhart. In 1919, Hess and Meyers described the peculiar yellow discoloration as "carotinemia," choosing this name on account of the carotinoid coloring matters, known as the lipochromes, which exist in carrots, green vegetables, oranges and
WISE F, DIASIO FA. CAROTINEMIA ASSOCIATED WITH DIABETES: REPORT OF A CASE. Arch Derm Syphilol. 1929;20(6):862–865. doi:10.1001/archderm.1929.01440060098010
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