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January 1930


Author Affiliations


From the Syphilis Division of the Medical Clinic, the Johns Hopkins Hospital.

Arch Derm Syphilol. 1930;21(1):32-39. doi:10.1001/archderm.1930.01440070040004

Considerable interest has recently been aroused, especially in Germany, as to the possibility that the prolonged use of arsphenamine products in civilized countries has appreciably altered the course of syphilitic infection. It is argued pro and con whether late syphilis, especially of the cardiovascular apparatus and of the nervous system, is increasing or decreasing, and whether the classic time relationships of the prearsphenamine era, between infection and the appearance of late manifestations, have been altered. A study of the literature convinces one that no definite statements can as yet be made as to a possible increase of aortic syphilis or neurosyphilis, but it does seem clear that the time interval between infection and the appearance of these or other late manifestations of syphilis has been shortened.

In addition, there is much speculation as to the production of an arsphenamine-resistant strain of Spirochaeta pallida with a consequent increase in so-called arsphenamine-resistant

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