Among the skin diseases that are now usually considered under the term "allergic condition," urticaria plays a prominent part. In all these diseases the question of sensitization and desensitization occupies at present a place of primary importance. The problem is especially difficult to grasp clinically and experimentally. It has been found that urticaria of internal origin has a counterpart in that of external origin, namely, the artificial wheal. The clinical and, as far as is known, the histologic pictures of both conditions have so much in common that there islittle reason to assume any important differences in their local genesis. On this general basis it is hoped, by the study of the artificial wheal, to arrive at some justifiable conclusions as to its relation to spontaneous urticaria.
One is inclined to regard some of the manifestations of so-called spontaneous urticaria as phenomena of sensitization and desensitization; in the first place,
CHEN FK. EXPERIMENTAL URTICARIA: ITS RELATION TO SPONTANEOUS URTICARIA. Arch Derm Syphilol. 1930;21(2):186–196. doi:10.1001/archderm.1930.01440080026005
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