In bismuth arsphenamine sulphonate (bismarsen) a distinct advance has been realized in syphilotherapy, especially since it represents the successful culmination of a long series of chemotherapeutic attempts to combine two such well known spirocheticidal agents as arsphenamine and bismuth in a single compound. It was synthesized by Dr. George W. Raiziss in 1925, and I have had the opportunity of using it since then in a combined clinical and laboratory investigation, the results of which are briefly summarized in this communication.
Stokes and Chambers1 reported that the toxicity of the drug is low, that reactions are comparatively benign and controllable, and that it is a useful alternate in cases in which other arsphenamines have produced cutaneous and hepatic reactions. They found it especially valuable in the treatment for cardiovascular syphilis, and taken all in all a compound of distinct value in syphilotherapy and especially in the prevention of late
KOLMER JA. BISMUTH ARSPHENAMINE SULPHONATE (BISMARSEN) IN THE TREATMENT OF SYPHILIS AND OF OTHER SPIROCHETIC INFECTIONS. Arch Derm Syphilol. 1930;21(3):394–412. doi:10.1001/archderm.1930.01440090042003
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