Since its introduction in 1921, by Sazerac and Levaditi, bismuth has rapidly proved its value as an antisyphilitic agent. Many articles have been written attesting to its great worth in patients, and also in animals experimentally infected with syphilis. As in the case of many new remedies some of the early reports have been ultra-enthusiastic. There are at present a number of different salts or compounds of bismuth on the market, so many, in fact, that it is difficult for a physician to evaluate properly the claims made for these various brands and to choose one to use in his practice.
A great deal of work remains to be done in regard to the pharmacology, toxicology and therapeutics of the bismuth preparations. We have attempted to aid in only one phase of this complicated problem, namely, in studying the absorption of the various brands of bismuth by means of roentgen
TEMPLETON HJ, RIX BM, THOMSON R. ABSORPTION RATE OF BISMUTH COMPOUNDS. Arch Derm Syphilol. 1930;21(5):739–756. doi:10.1001/archderm.1930.01440110021003
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