It is generally admitted that one of the most vexing problems in syphilology today is the pathogenesis of, and more particularly the best therapeutic procedure in, icterus developing during or after a course of organic arsenical injections. In this regard, the most recent opinions of Milian, Ravaut and a number of other French authors are of special interest. On the basis of a study of 118 cases of icterus of this sort, Milian1 insisted on the continued use of the arsenical compounds in post-therapeutic types of icterus or in those developing from two weeks to several months or more after the last injection. He believed all of these to be of a syphilitic nature, and he stands almost alone in his therapeutic advice. Of 105 patients who had received treatment before the icterus developed, 75 had this post-therapeutic type.
Ravaut,2 Lortat, Jacob, Sezary and Simon,3 with 111
GREENBAUM SS. HEPATORECURRENT SYPHILIS: REPORT OF A CASE TERMINATING IN ACUTE YELLOW ATROPHY. Arch Derm Syphilol. 1930;21(5):771–776. doi:10.1001/archderm.1930.01440110053006
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