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Article
June 1930

PIGMENT (MELANIN) STUDIES OF THE HUMAN SKIN AFTER APPLICATION OF THORIUM X: WITH SPECIAL REFERENCE TO THE ORIGIN AND FUNCTION OF DENDRITIC CELLS

Author Affiliations

NEW YORK

From the Dermatologische Klinik, University of Zurich, Prof. Bruno Bloch, Director.

Arch Derm Syphilol. 1930;21(6):916-956. doi:10.1001/archderm.1930.01440120010002
Abstract

Pigment (melanin) is found in the human epidermis in the basal and overlying cells as well as in a more bizarre appearing cell with dendritic processes. Such dendritic cells are also found in the matrix of pigmented hairs, epidermal hair sheets, sometimes in the epidermal parts of sebaceous glands and in pigmented mucous membranes. They are increased in hyperpigmented processes at the time of pigment formation, especially after exposure to light, x-rays, radium and thorium X. They are well seen in acanthotic processes such as condylomas, lichen ruber, molluscum contagiosum, psoriasis and pemphigus vegetans, as well as in the early stages of melanocarcinomas. In hyperpigmented and acanthotic processes they may be found in the layers above the basal cells.

While as a rule it is true that dendritic cells are increased in number and therefore better seen in hyperpigmented skins, for reasons not yet clear they are better visualized in

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