The second decade of what must have been termed before now, and with aptness, the "new era" in the treatment of patients with syphilis is drawing to a close. Time enough has elapsed to justify some definiteness of opinion as to the merits of modern therapy.
A minority remain unconvinced that Ehrlich's contributions to the therapy for syphilis, and all the other additions to the treatment with mercury and the iodides, have lessened the final damage that is directly traceable to syphilis. They claim: (1) that "cures" are never demonstrable; (2) that modern treatment, particularly when administered early in the infection, does not eradicate the disease, but does materially hinder the patient's natural defensive mechanism; (3) that the principal changes lie in the structures involved, cutaneous and other superficial manifestations that are important to the natural defensive mechanism being less frequent now, and deeper involvement being more frequent, more probable
NORRIS CB. MODERN ANTISYPHILITIC THERAPY: DISADVANTAGES AND VALUE: A STATISTICAL STUDY OF ONE HUNDRED AND NINETY-TWO CASES OF RELATIVELY LATE SYPHILIS, UNTREATED AND INADEQUATELY TREATED. Arch Derm Syphilol. 1930;21(6):985–1001. doi:10.1001/archderm.1930.01440120087006
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