The study of the localization of syphilitic lesions has always been important, not only because of the interest in the natural history of the disease, but because of the bearing it may have on therapy. Recently, interest has been revived in the time-worn observation of the infrequency of a history of antecedent syphilitic skin lesions in patients suffering from neurosyphilis. Moore,1 from this clinic, in a series of papers reporting the results of clinical studies in asymptomatic neurosyphilis, analyzed in detail the association of asymptomatic neurosyphilis with other manifestations of syphilis. A search through the literature did not reveal any accurate studies of the types of associated complicating tertiary syphilitic lesions in manifest clinical neurosyphilis, and I have been led to record my observations in this paper.
At the time this paper was written, 1,371 patients with clinically evident syphilis of the central nervous system have been examined during
HOPKINS HH. ASSOCIATION OF CLINICAL NEUROSYPHILIS WITH VARIOUS TYPES OF TERTIARY SYPHILIS. Arch Derm Syphilol. 1930;22(2):232–236. doi:10.1001/archderm.1930.01440140034003
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